Scholar Response

Response Fields

Field Type Description Example
lens_id String Unique lens identifier 100-004-910-081-14X
created Date Record created date 2016-08-01T00:00:00+00:00
publication_type String (Publication Types) Publication Type journal article
publication_supplementary_type Array of String Supplementary publication type ["review"]
authors Array of Author Authors  
title String Title of the scholarly work Malaria
external_ids Array of Ids The external identifier(s) for a scholarly work (DOI, PubMed ID, PubMed Central ID, Microsoft Academic ID or CORE)  
start_page String Start page 893
end_page String End page 916
volume String Volume 32
issue String Issue 4
languages Array of String Languages ["en"]
references List of References References  
references_count Integer The number of works in the reference list of a scholarly work 22
references_resolved_count Integer The number of works in the reference list of a scholarly work that have been resolved to a scholarly work Lens Id 21
scholarly_citations List of Lens Ids Scholarly Citations ["091-020-924-584-261", "159-770-478-635-994", ...]
scholarly_citations_count Integer The number of scholarly works that cite this scholarly work 3
patent_citations Array of Patent Citation Referenced by patents  
patent_citations_count Integer Number of patent citations 10
chemicals List of Chemical Chemicals  
clinical_trials List of Clinical Trial Clinical Trials  
fields_of_study List of String Fields Of Study ["Immunology", "Malaria"]
source_urls List of Source URL Source Urls  
abstract String Scholarly work abstract text  
date_published Date Date of publication 2009-05-22
date_published_parts Array of Integer Consist of year, month and day [1974, 1, 6]
year_published Integer Year of publication 1986
conference Conference The conference instance or edition  
author_count Integer Number of Authors 4
open_access Open Access    
source Source Source publication in which the scholarly work appears  
keywords Array of String Keywords  
mesh_terms Array of MeSH Term MeSH term  
funding Array of Funding Funding  

Patent Citation

Field Type Description Example
lens_id String Unique lens identifier 141-171-521-309-804

Author

Field Type Description Example
collective_name String Author Collective Name  
first_name String The author’s first name Alexander
last_name String The author’s last name Kupco
initials String Author Initials A
affiliations Array of Affiliation The institution/affiliations associated with Author.  
ids Array of Ids Author’s MAG, ORCID identifiers [{"type": "magid", "value": "1234567890"}]

Affiliation

Field Type Description Example
name String The institution associated with the author affiliations. Stony Brook University
name_original String The author’s original affiliation including the institution name and address. School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts USA
grid_id String Affiliation grid id. NB This field is deprecated, please use the ids field instead. grid.9018.0
country_code String Comma separated country codes DE
ids Array of Ids The external institution identifiers associated with the author’s affiliation  

References

Field Type Description Example
lens_id String Unique lens identifier 041-778-570-427-167
text String The the original text string in the references Haddaway, N. R. & Verhoeven, J. T. Ecol. Evol. 5, 4451–4454 (2015).

Open Access

Field Type Description Example
license String The Open Access license type cc-by
colour String The Open Access colour category gold
locations [Open Access Location] The Open Access Locations  

Source

Field Type Description Example
title String The name of source publication in which the scholarly work appears Journal name, Book title, Confernce proceedings
type String Source Type Journal
publisher String The publisher of the source publication W.B. Saunders Ltd
issn Array of Object ISSN [{"value": "10797114"}]
country String The publisher’s country United Kingdom
asjc_codes String The All Science Journal Classification (ASJC) code 2735
asjc_subjects String Subject is derived from journals descriptions in Crossref metadata based on the Science Journal Classification Codes Pediatrics

Mesh Term

Field Type Description Example
mesh_id String MeSH term unique identifier. MeSH terms are the National Library of Medicine’s controlled vocabulary or subject heading list. D000293
mesh_heading String MeSH terms are the National Library of Medicine’s controlled vocabulary or medical subject headings assigned to PubMed entries. NB MeSH Headings are case sensitive. Adolescent
qualifier_id String Mesh Term Qualifier ID Q000032
qualifier_name String Mesh Term Qualifier Name analysis

ISSN

Field Type Description Example
value String The International Standard Serial Number 10797114
type String ISSN type print, electronic

Funding

Field Type Description Example
org String Name of the funding organisation NIDCR NIH HHS
funding_id String The funding organisation’s project identifier U01 DE018902
country String The country of the funding body United States

Conference

Field Type Description Example
name String Conference Name International Electron Devices Meeting
instance String Conference Instance Name CHI 1985
location String The location of the conference Lihue, Kauai, HA, USA

Chemical

Field Type Description Example
mesh_id String MeSH term id D000293
registry_number String Chemical registration number 5Q7ZVV76EI
substance_name String Substance name Antimalarials

Clinical Trial

Field Type Description Example
id String Identifier nct00105716
registry String Clinical Trial Registry 10.18810/clinical-trials-gov

Source URL

Field Type Description Example
type String Source URL Type html, pdf, unknown
url String URL String http://cds.cern.ch/record/2291692

Ids

Field Type Description Example
type String The type/s of external identifiers for the scholarly work, author, institution, etc. doi, pmid, magid, orcid, grid, ror, etc.
value String The external identifier(s) for the scholarly work, author, institution, etc. 10.1016/s0031-3955(16)34861-1, 0000-0003-3902-2234, grid.425957.8, 056x7d368, etc.

Open Access Location

Field | Type | Description | Example ——- |:—————:|——————-|——— landing_page_urls | Array of String | Landing page urls | ["https://europepmc.org/articles/pmc5024789"] pdf_urls | Array of String | PDF urls | ["http://www.ejcancer.com/article/S0959804915004505/pdf"]

Enums

Publication Types

journal article, letter, editorial, news, book, book chapter, conference proceedings article, conference proceedings, dataset, journal, journal issue, journal volume, report, standard, dissertation, clinical trial, clinical study, libguide, reference entry, working paper, component, review, preprint, other, unknown

Sample API Response

Request:

{
  "query":{
  	"match":{"lens_id":"086-713-276-176-892"}
  }
}

Response:

{
    "total": 1,
    "max_score": 19.05009,
    "data": [
        {
            "lens_id": "086-713-276-176-892",
            "title": "A randomised non-comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel-pretreated castration-resistant prostate cancer",
            "publication_type": "journal article",
            "year_published": 2015,
            "date_published": "2015-06-13T00:00:00.000000+00:00",
            "date_published_parts": [
                2015,
                6,
                13
            ],
            "created": "2018-05-12T02:39:28.395000+00:00",
            "external_ids": [
                {
                    "type": "coreid",
                    "value": "82196673"
                },
                {
                    "type": "pmid",
                    "value": "26082390"
                },
                {
                    "type": "doi",
                    "value": "10.1016/j.ejca.2015.05.019"
                },
                {
                    "type": "pmcid",
                    "value": "pmc5024789"
                },
                {
                    "type": "magid",
                    "value": "2113210954"
                }
            ],
            "patent_citations": [
                {
                    "lens_id": "122-064-734-901-067"
                }
            ],
            "patent_citations_count": 1,
            "open_access": {
                "locations": {
                    "landing_page_urls": [
                        "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024789/",
                        "https://doi.org/10.1016/j.ejca.2015.05.019",
                        "https://europepmc.org/articles/pmc5024789",
                        "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024789"
                    ],
                    "pdf_urls": [
                        "http://www.ejcancer.com/article/S0959804915004505/pdf",
                        "https://europepmc.org/articles/pmc5024789?pdf=render"
                    ]
                },
                "license": "cc-by-nc-nd",
                "colour": "hybrid"
            },
            "authors": [
                {
                    "first_name": "Maha",
                    "last_name": "Hussain",
                    "initials": "M",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2105158973"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "University of Michigan",
                            "name_original": "University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States;",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "27837315"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.214458.e"
                                },
                                {
                                    "type": "isni",
                                    "value": "0000000419367347"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100007270"
                                },
                                {
                                    "type": "ror",
                                    "value": "00jmfr291"
                                }
                            ],
                            "grid_id": "grid.214458.e",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Dana E.",
                    "last_name": "Rathkopf",
                    "initials": "DE",
                    "ids": [
                        {
                            "type": "orcid",
                            "value": "0000-0002-4503-7582"
                        },
                        {
                            "type": "magid",
                            "value": "722834404"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Memorial Sloan Kettering Cancer Center",
                            "name_original": "Memorial Sloan Kettering New York NY United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "1334819555"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.51462.34"
                                },
                                {
                                    "type": "ror",
                                    "value": "02yrq0923"
                                }
                            ],
                            "grid_id": "grid.51462.34",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Glenn",
                    "last_name": "Liu",
                    "initials": "G",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2133546628"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "University of Wisconsin-Madison",
                            "name_original": "University of Wisconsin, Carbone Cancer Center, Madison, WI, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "135310074"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.14003.36"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100007015"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q838330"
                                },
                                {
                                    "type": "ror",
                                    "value": "01y2jtd41"
                                }
                            ],
                            "grid_id": "grid.14003.36",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Andrew J.",
                    "last_name": "Armstrong",
                    "initials": "AJ",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2172156363"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Duke University",
                            "name_original": "Duke Cancer Institute and Duke Prostate Center, Duke University, Durham, NC, United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "170897317"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.26009.3d"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100006510"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q168751"
                                },
                                {
                                    "type": "ror",
                                    "value": "00py81415"
                                }
                            ],
                            "grid_id": "grid.26009.3d",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Kevin",
                    "last_name": "Kelly",
                    "initials": "K",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2097407452"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Thomas Jefferson University",
                            "name_original": "Thomas Jefferson Univ., Philadelphia, PA (United States)",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "149251103"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.265008.9"
                                },
                                {
                                    "type": "ror",
                                    "value": "00ysqcn41"
                                }
                            ],
                            "grid_id": "grid.265008.9",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Anna C.",
                    "last_name": "Ferrari",
                    "initials": "AC",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2312728207"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "New York University",
                            "name_original": "New York University Clinical Cancer Center, New York, NY, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "57206974"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.137628.9"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100006732"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q49210"
                                },
                                {
                                    "type": "ror",
                                    "value": "0190ak572"
                                }
                            ],
                            "grid_id": "grid.137628.9",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "John D.",
                    "last_name": "Hainsworth",
                    "initials": "JD",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2145549068"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Sarah Cannon Research Institute",
                            "name_original": "Sarah Cannon Research Institute, Nashville, TN, United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "172427033"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.477834.b"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q30270369"
                                },
                                {
                                    "type": "ror",
                                    "value": "03cp5cj42"
                                }
                            ],
                            "grid_id": "grid.477834.b",
                            "country_code": "GB"
                        }
                    ]
                },
                {
                    "first_name": "Adarsh",
                    "last_name": "Joshi",
                    "initials": "A",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2097035297"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Rebecca R.",
                    "last_name": "Hozak",
                    "initials": "RR",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2182553763"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Indianapolis, IN (United States)",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Ling",
                    "last_name": "Yang",
                    "initials": "L",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2250633597"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Jonathan D.",
                    "last_name": "Schwartz",
                    "initials": "JD",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2155041711"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Celestia S.",
                    "last_name": "Higano",
                    "initials": "CS",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2560077320"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Fred Hutchinson Cancer Research Center",
                            "name_original": "University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, United States",
                            "ids": [
                                {
                                    "type": "grid",
                                    "value": "grid.270240.3"
                                },
                                {
                                    "type": "ror",
                                    "value": "007ps6h72"
                                }
                            ],
                            "grid_id": "grid.270240.3",
                            "country_code": "US"
                        },
                        {
                            "name": "University of Washington",
                            "name_original": "University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, United States",
                            "ids": [
                                {
                                    "type": "fundref",
                                    "value": "100007812"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.34477.33"
                                },
                                {
                                    "type": "ror",
                                    "value": "00cvxb145"
                                }
                            ],
                            "grid_id": "grid.34477.33",
                            "country_code": "US"
                        }
                    ]
                }
            ],
            "source": {
                "title": "European journal of cancer (Oxford, England : 1990)",
                "type": "Journal",
                "publisher": "Elsevier Limited",
                "issn": [
                    {
                        "type": "unknown",
                        "value": "18790852"
                    },
                    {
                        "type": "print",
                        "value": "09598049"
                    }
                ],
                "country": "United Kingdom",
                "asjc_codes": [
                    "1306",
                    "2730"
                ],
                "asjc_subjects": [
                    "Cancer Research",
                    "Oncology"
                ]
            },
            "fields_of_study": [
                "Internal medicine",
                "Oncology",
                "Cixutumumab",
                "Prednisone",
                "Ramucirumab",
                "Prostate cancer",
                "Mitoxantrone",
                "Docetaxel",
                "Regimen",
                "Phases of clinical research",
                "Medicine"
            ],
            "keywords": [
                "Cixutumumab",
                "Mitoxantrone",
                "Prednisone",
                "Prostate cancer",
                "Ramucirumab"
            ],
            "publication_supplementary_type": [
                "clinical trial, phase ii",
                "multicenter study",
                "randomized controlled trial",
                "research support, non-u.s. gov't"
            ],
            "volume": "51",
            "issue": "13",
            "languages": [
                "en"
            ],
            "references": [
                {
                    "lens_id": "003-415-704-045-340",
                    "text": "Wilke . Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial, Lancet Oncol. 2014; 15 1224."
                },
                {
                    "lens_id": "006-027-163-131-418",
                    "text": "Pandini . Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells, Cancer Res. 2005; 65 1849."
                },
                {
                    "lens_id": "010-839-632-959-305",
                    "text": "Spratlin . Ramucirumab (IMC-1121B): monoclonal antibody inhibition of vascular endothelial growth factor receptor-2, Curr Oncol Rep. 2011; 13 97."
                },
                {
                    "lens_id": "013-690-046-069-453",
                    "text": "Strohmeyer . Vascular endothelial growth factor and its correlation with angiogenesis and p53 expression in prostate cancer, Prostate. 2000; 45 216."
                },
                {
                    "lens_id": "015-449-984-502-884",
                    "text": "Int J Oncol. 2006 Mar;28(3):723-30"
                },
                {
                    "lens_id": "015-767-931-570-158",
                    "text": "Fuchs . Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial, Lancet. 2014; 383 31."
                },
                {
                    "lens_id": "018-245-327-947-052"
                },
                {
                    "lens_id": "020-963-415-260-304",
                    "text": "Wu . Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors, Clin Cancer Res. 2006; 12 (20 Pt 1) 6153."
                },
                {
                    "lens_id": "026-332-934-265-841",
                    "text": "Rubin . Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis, Prostate. 2004; 58 41."
                },
                {
                    "lens_id": "028-101-820-366-93X",
                    "text": "Garon . Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial, Lancet. 2014; 384 665."
                },
                {
                    "lens_id": "032-523-762-689-478",
                    "text": "Cancer Res. 2001 Mar 15;61(6):2533-6"
                },
                {
                    "lens_id": "037-117-740-052-570",
                    "text": "Doll . Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate, Prostate. 2001; 49 293."
                },
                {
                    "lens_id": "038-557-040-762-884",
                    "text": "Kawada . Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer, Cancer Res. 2006; 66 4419."
                },
                {
                    "lens_id": "040-239-601-782-040",
                    "text": "Burfeind . Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo, Proc Natl Acad Sci USA. 1996; 93 7263."
                },
                {
                    "lens_id": "042-246-996-698-043",
                    "text": "Bähr . The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function, Growth Factors. 2005; 23 1."
                },
                {
                    "lens_id": "043-024-349-674-734"
                },
                {
                    "lens_id": "043-201-312-439-671",
                    "text": "Clin Cancer Res. 2002 Aug;8(8):2714-24"
                },
                {
                    "lens_id": "043-546-849-370-25X",
                    "text": "Khandwala . The effects of insulin-like growth factors on tumorigenesis and neoplastic growth, Endocr Rev. 2000; 21 215."
                },
                {
                    "lens_id": "046-041-414-632-674",
                    "text": "Rowinsky . Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers, Curr Drug Targets. 2011; 12 2016."
                },
                {
                    "lens_id": "046-648-350-541-685",
                    "text": "Sternberg . Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial, J Clin Oncol. 2009; 27 5431."
                },
                {
                    "lens_id": "046-852-526-558-260",
                    "text": "Tannock . Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer, N Engl J Med. 2004; 351 1502."
                },
                {
                    "lens_id": "054-808-246-993-497",
                    "text": "Scher . Design and end points of phase 2 trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group (PCWG2), J Clin Oncol. 2008; 26 1148."
                },
                {
                    "lens_id": "059-727-763-246-876",
                    "text": "Alva . The changing natural history of metastatic prostate cancer, Cancer J. 2013; 19 19."
                },
                {
                    "lens_id": "065-982-455-260-233",
                    "text": "Tannock . Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points, J Clin Oncol. 1996; 14 1756."
                },
                {
                    "lens_id": "069-612-901-254-771"
                },
                {
                    "lens_id": "070-794-057-102-152",
                    "text": "Spratlin . Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2, J Clin Oncol. 2010; 28 780."
                },
                {
                    "lens_id": "083-233-359-584-62X",
                    "text": "Hwang . Angiogenesis inhibitors in the treatment of prostate cancer, J Hematol Oncol. 2010; 3 26."
                },
                {
                    "lens_id": "087-375-055-670-659",
                    "text": "Blum . Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics, J Biol Chem. 2003; 278 40442."
                },
                {
                    "lens_id": "087-458-139-690-01X",
                    "text": "de Bono . Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial, Lancet. 2010; 376 1147."
                },
                {
                    "lens_id": "090-234-280-758-859",
                    "text": "Yu . SWOG S0925: a randomized phase II study of androgen deprivation combined with cixutumumab versus androgen deprivation alone in patients with new metastatic hormone-sensitive prostate cancer, J Clin Oncol. 2015; 33 1601."
                },
                {
                    "lens_id": "094-489-992-059-749",
                    "text": "Petrylak . Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer, N Engl J Med. 2004; 351 1513."
                },
                {
                    "lens_id": "096-654-301-744-608",
                    "text": "Wu . In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors, Clin Cancer Res. 2005; 11 3065."
                },
                {
                    "lens_id": "101-625-667-760-940",
                    "text": "Clin Cancer Res. 2000 May;6(5):1882-90"
                },
                {
                    "lens_id": "113-073-836-369-700",
                    "text": "Cancer Res. 2003 Dec 15;63(24):8912-21"
                },
                {
                    "lens_id": "128-335-721-572-401"
                },
                {
                    "lens_id": "155-152-241-876-905",
                    "text": "Mauro . Role of the IGF-I receptor in the regulation of cell–cell adhesion: implications in cancer development and progression, J Cell Physiol. 2003; 194 108."
                }
            ],
            "mesh_terms": [
                {
                    "mesh_heading": "Adenocarcinoma",
                    "qualifier_name": "drug therapy",
                    "mesh_id": "D000230",
                    "qualifier_id": "Q000188"
                },
                {
                    "mesh_heading": "Adolescent",
                    "mesh_id": "D000293"
                },
                {
                    "mesh_heading": "Adult",
                    "mesh_id": "D000328"
                },
                {
                    "mesh_heading": "Aged",
                    "mesh_id": "D000368"
                },
                {
                    "mesh_heading": "Antibodies, Monoclonal",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D000911",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Antibodies, Monoclonal, Humanized",
                    "mesh_id": "D061067"
                },
                {
                    "mesh_heading": "Antineoplastic Combined Chemotherapy Protocols",
                    "qualifier_name": "adverse effects",
                    "mesh_id": "D000971",
                    "qualifier_id": "Q000009"
                },
                {
                    "mesh_heading": "Disease Progression",
                    "mesh_id": "D018450"
                },
                {
                    "mesh_heading": "Disease-Free Survival",
                    "mesh_id": "D018572"
                },
                {
                    "mesh_heading": "Docetaxel",
                    "mesh_id": "D000077143"
                },
                {
                    "mesh_heading": "Humans",
                    "mesh_id": "D006801"
                },
                {
                    "mesh_heading": "Kaplan-Meier Estimate",
                    "mesh_id": "D053208"
                },
                {
                    "mesh_heading": "Male",
                    "mesh_id": "D008297"
                },
                {
                    "mesh_heading": "Middle Aged",
                    "mesh_id": "D008875"
                },
                {
                    "mesh_heading": "Mitoxantrone",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D008942",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Prednisone",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D011241",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Proportional Hazards Models",
                    "mesh_id": "D016016"
                },
                {
                    "mesh_heading": "Prostatic Neoplasms, Castration-Resistant",
                    "qualifier_name": "drug therapy",
                    "mesh_id": "D064129",
                    "qualifier_id": "Q000188"
                },
                {
                    "mesh_heading": "Taxoids",
                    "qualifier_name": "therapeutic use",
                    "mesh_id": "D043823",
                    "qualifier_id": "Q000627"
                },
                {
                    "mesh_heading": "Time Factors",
                    "mesh_id": "D013997"
                },
                {
                    "mesh_heading": "Treatment Outcome",
                    "mesh_id": "D016896"
                },
                {
                    "mesh_heading": "United States",
                    "mesh_id": "D014481"
                },
                {
                    "mesh_heading": "Young Adult",
                    "mesh_id": "D055815"
                },
                {
                    "mesh_heading": "Ramucirumab",
                    "mesh_id": "D000096662"
                }
            ],
            "chemicals": [
                {
                    "substance_name": "Antibodies, Monoclonal",
                    "registry_number": "0",
                    "mesh_id": "D000911"
                },
                {
                    "substance_name": "Antibodies, Monoclonal, Humanized",
                    "registry_number": "0",
                    "mesh_id": "D061067"
                },
                {
                    "substance_name": "Taxoids",
                    "registry_number": "0",
                    "mesh_id": "D043823"
                },
                {
                    "substance_name": "Docetaxel",
                    "registry_number": "15H5577CQD",
                    "mesh_id": "D000077143"
                },
                {
                    "substance_name": "cixutumumab",
                    "registry_number": "2285XW22DR",
                    "mesh_id": "C557414"
                },
                {
                    "substance_name": "Mitoxantrone",
                    "registry_number": "BZ114NVM5P",
                    "mesh_id": "D008942"
                },
                {
                    "substance_name": "Prednisone",
                    "registry_number": "VB0R961HZT",
                    "mesh_id": "D011241"
                }
            ],
            "clinical_trials": [
                {
                    "id": "nct00683475",
                    "registry": "10.18810/clinical-trials-gov"
                }
            ],
            "funding": [
                {
                    "org": "NCI NIH HHS",
                    "funding_id": "P30 CA008748",
                    "country": "United States"
                }
            ],
            "source_urls": [
                {
                    "type": "html",
                    "url": "https://www.scholars.northwestern.edu/en/publications/a-randomised-non-comparative-phase-ii-trial-of-cixutumumab-imc-a1"
                },
                {
                    "type": "html",
                    "url": "https://www.sciencedirect.com/science/article/pii/S0959804915004505"
                },
                {
                    "type": "html",
                    "url": "https://core.ac.uk/display/82196673"
                },
                {
                    "type": "html",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26082390"
                },
                {
                    "type": "html",
                    "url": "https://europepmc.org/abstract/MED/26082390"
                },
                {
                    "type": "html",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26082390/"
                },
                {
                    "type": "unknown",
                    "url": "https://www.sciencedirect.com/science/article/abs/pii/S0959804915004505#!"
                },
                {
                    "type": "core_fulltext",
                    "url": "https://core.ac.uk/download/pdf/82196673.pdf"
                }
            ],
            "abstract": "Abstract Background Cixutumumab, a human monoclonal antibody (HuMAb), targets the insulin-like growth factor receptor...",
            "references_count": 36,
            "references_resolved_count": 36,
            "scholarly_citations_count": 30,
            "start_page": "1714",
            "end_page": "1724",
            "scholarly_citations": [
                "000-201-187-558-654",
                "003-526-658-910-015",
                "003-873-121-875-383",
                "007-302-126-599-214",
                "010-213-946-021-323",
                "013-615-059-072-408",
                "013-724-699-030-436",
                "014-223-693-822-29X",
                "018-109-129-610-567",
                "021-609-846-309-864",
                "026-107-871-228-662",
                "026-389-814-274-812",
                "028-262-672-178-175",
                "030-115-779-382-725",
                "035-630-845-016-108",
                "037-016-998-061-439",
                "041-068-995-918-23X",
                "046-312-772-821-709",
                "054-371-103-868-542",
                "055-935-439-115-752",
                "059-021-699-657-683",
                "062-343-220-167-149",
                "067-043-485-486-441",
                "085-619-841-835-92X",
                "086-063-652-233-255",
                "106-358-426-773-191",
                "132-091-200-995-616",
                "145-126-752-104-913",
                "149-831-451-273-472",
                "153-500-774-834-922"
            ],
            "author_count": 12,
            "is_open_access": true
        }
    ],
    "results": 1
}