Scholar Response

Response Fields

Field Type Description Example
patent_citations Array of Patent Citation Referenced by patents  
patent_citations_count Integer Number of patent citations 10
lens_id String Unique lens identifier 100-004-910-081-14X
created Date Record created date 2016-08-01T00:00:00+00:00
publication_type String (Publication Types) Publication Type journal article
publication_supplementary_type Array of String Supplementary publication type ["review"]
authors Array of Author Authors  
title String Title of the scholarly work Malaria
external_ids Array of Ids The external identifier(s) for a scholarly work (DOI, PubMed ID, PubMed Central ID, Microsoft Academic ID or CORE)  
start_page String Start page 893
end_page String End page 916
volume String Volume 32
issue String Issue 4
languages Array of String Languages ["en"]
references List of Reference References  
scholarly_citations List of Lens Ids Scholarly Citations ["091-720-300-990-437"]
chemicals List of Chemical Chemicals  
clinical_trials List of Clinical Trial Clinical Trials  
fields_of_study List of String Fields Of Study ["Immunology", "Malaria"]
source_urls List of Source URL Source Urls  
abstract String Scholarly work abstract text  
date_published Date Date of publication 2009-05-22
date_published_parts Array of Integer Consist of year, month and day [1974, 1, 6]
year_published Integer Year of publication 1986
conference Conference The conference instance or edition  
author_count Integer Number of Authors 4
references_count Integer The number of works in the reference list of a scholarly work 2
scholarly_citations_count Integer The number of scholarly works that cite this scholarly work 3
open_access Open Access    
source Source Source publication in which the scholarly work appears  
keywords Array of String Keywords  
mesh_terms Array of MeSH Term MeSH term  
funding Array of Funding Funding  

Patent Citation

Field Type Description Example
lens_id String Unique lens identifier 141-171-521-309-804

Author

Field Type Description Example
collective_name String Author Collective Name  
first_name String The author’s first name Alexander
last_name String The author’s last name Kupco
initials String Author Initials A
affiliations Array of Affiliation The institution/affiliations associated with Author.  
ids Array of Ids Author’s MAG, ORCID identifiers [{"type": "magid", "value": "1234567890"}]

Affiliation

Field Type Description Example
name String The institution associated with the author affiliations. Stony Brook University
name_original String The author’s original affiliation including the institution name and address. School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts USA
grid_id String Affiliation grid id. NB This field is deprecated, please use the ids field instead. grid.9018.0
country_code String Comma separated country codes DE
ids Array of Ids The external institution identifiers associated with the author’s affiliation  

Reference

Field Type Description Example
lens_id String Unique lens identifier 071-957-228-698-625

Open Access

Field Type Description Example
license String The Open Access license type cc-by
colour String The Open Access colour category gold

Source

Field Type Description Example
title String The name of source publication in which the scholarly work appears Journal name, Book title, Confernce proceedings
type String Source Type Journal
publisher String The publisher of the source publication W.B. Saunders Ltd
issn Array of Object ISSN [{"value": "10797114"}]
country String The publisher’s country United Kingdom
asjc_codes String The All Science Journal Classification (ASJC) code 2735
asjc_subjects String Subject is derived from journals descriptions in Crossref metadata based on the Science Journal Classification Codes Pediatrics

Mesh Term

Field Type Description Example
mesh_id String MeSH term unique identifier. MeSH terms are the National Library of Medicine’s controlled vocabulary or subject heading list. D000293
mesh_heading String MeSH terms are the National Library of Medicine’s controlled vocabulary or medical subject headings assigned to PubMed entries. NB MeSH Headings are case sensitive. Adolescent
qualifier_id String Mesh Term Qualifier ID Q000032
qualifier_name String Mesh Term Qualifier Name analysis

ISSN

Field Type Description Example
value String The International Standard Serial Number 10797114
type String ISSN type print, electronic

Funding

Field Type Description Example
org String Name of the funding organisation NIDCR NIH HHS
funding_id String The funding organisation’s project identifier U01 DE018902
country String The country of the funding body United States

Conference

Field Type Description Example
name String Conference Name International Electron Devices Meeting
instance String Conference Instance Name CHI 1985
location String The location of the conference Lihue, Kauai, HA, USA

Chemical

Field Type Description Example
mesh_id String MeSH term id D000293
registry_number String Chemical registration number 5Q7ZVV76EI
substance_name String Substance name Antimalarials

Clinical Trial

Field Type Description Example
id String Identifier nct00105716
registry String Clinical Trial Registry 10.18810/clinical-trials-gov

Source URL

Field Type Description Example
type String Source URL Type html
url String URL String http://cds.cern.ch/record/2291692

Ids

Field Type Description Example
type String The type/s of external identifiers for the scholarly work, author, institution, etc. doi, pmid, magid, orcid, grid, ror, etc.
value String The external identifier(s) for the scholarly work, author, institution, etc. 10.1016/s0031-3955(16)34861-1, 0000-0003-3902-2234, grid.425957.8, 056x7d368, etc.

Enums

Publication Types

journal article, letter, editorial, news, book, book chapter, conference proceedings article, conference proceedings, dataset, journal, journal issue, journal volume, report, standard, dissertation, clinical trial, clinical study, libguide, reference entry, working paper, component, review, preprint, other, unknown

Sample API Response

Request:

{
  "query":{
  	"match":{"lens_id":"086-713-276-176-892"}
  }
}

Response:

{
    "total": 1,
    "max_score": 18.879501,
    "data": [
        {
            "lens_id": "086-713-276-176-892",
            "title": "A randomised non-comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel-pretreated castration-resistant prostate cancer",
            "publication_type": "journal article",
            "year_published": 2015,
            "date_published": "2015-06-13T00:00:00.000000+00:00",
            "date_published_parts": [
                2015,
                6,
                13
            ],
            "created": "2018-05-12T02:39:28.395000+00:00",
            "external_ids": [
                {
                    "type": "pmcid",
                    "value": "pmc5024789"
                },
                {
                    "type": "coreid",
                    "value": "82196673"
                },
                {
                    "type": "magid",
                    "value": "2113210954"
                },
                {
                    "type": "pmid",
                    "value": "26082390"
                },
                {
                    "type": "doi",
                    "value": "10.1016/j.ejca.2015.05.019"
                }
            ],
            "patent_citations": [
                {
                    "lens_id": "122-064-734-901-067"
                }
            ],
            "patent_citations_count": 1,
            "open_access": {
                "license": "cc-by-nc-nd",
                "colour": "hybrid"
            },
            "authors": [
                {
                    "first_name": "Maha",
                    "last_name": "Hussain",
                    "initials": "M",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2105158973"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "University of Michigan",
                            "name_original": "University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, United States;",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "27837315"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.214458.e"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100007270"
                                },
                                {
                                    "type": "ror",
                                    "value": "00jmfr291"
                                }
                            ],
                            "grid_id": "grid.214458.e",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Dana E.",
                    "last_name": "Rathkopf",
                    "initials": "DE",
                    "ids": [
                        {
                            "type": "orcid",
                            "value": "0000-0002-4503-7582"
                        },
                        {
                            "type": "magid",
                            "value": "722834404"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Memorial Sloan Kettering Cancer Center",
                            "name_original": "Memorial Sloan Kettering New York NY United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "1334819555"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.51462.34"
                                },
                                {
                                    "type": "ror",
                                    "value": "02yrq0923"
                                }
                            ],
                            "grid_id": "grid.51462.34",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Glenn",
                    "last_name": "Liu",
                    "initials": "G",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2133546628"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "University of Wisconsin-Madison",
                            "name_original": "University of Wisconsin, Carbone Cancer Center, Madison, WI, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "135310074"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.14003.36"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100007015"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q838330"
                                },
                                {
                                    "type": "ror",
                                    "value": "01y2jtd41"
                                }
                            ],
                            "grid_id": "grid.14003.36",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Andrew J.",
                    "last_name": "Armstrong",
                    "initials": "AJ",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2172156363"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Duke University",
                            "name_original": "Duke Cancer Institute and Duke Prostate Center, Duke University, Durham, NC, United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "170897317"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.26009.3d"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100006510"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q168751"
                                },
                                {
                                    "type": "ror",
                                    "value": "00py81415"
                                }
                            ],
                            "grid_id": "grid.26009.3d",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Kevin",
                    "last_name": "Kelly",
                    "initials": "K",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2097407452"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Thomas Jefferson University",
                            "name_original": "Thomas Jefferson Univ., Philadelphia, PA (United States)",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "149251103"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.265008.9"
                                },
                                {
                                    "type": "ror",
                                    "value": "00ysqcn41"
                                }
                            ],
                            "grid_id": "grid.265008.9",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Anna C.",
                    "last_name": "Ferrari",
                    "initials": "AC",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2312728207"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "New York University",
                            "name_original": "New York University Clinical Cancer Center, New York, NY, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "57206974"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.137628.9"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100006732"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q49210"
                                },
                                {
                                    "type": "ror",
                                    "value": "0190ak572"
                                }
                            ],
                            "grid_id": "grid.137628.9",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "John D.",
                    "last_name": "Hainsworth",
                    "initials": "JD",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2145549068"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Sarah Cannon Research Institute",
                            "name_original": "Sarah Cannon Research Institute, Nashville, TN, United States",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "172427033"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.477834.b"
                                },
                                {
                                    "type": "wikidata",
                                    "value": "q30270369"
                                },
                                {
                                    "type": "ror",
                                    "value": "03cp5cj42"
                                }
                            ],
                            "grid_id": "grid.477834.b",
                            "country_code": "GB"
                        }
                    ]
                },
                {
                    "first_name": "Adarsh",
                    "last_name": "Joshi",
                    "initials": "A",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2097035297"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Rebecca R.",
                    "last_name": "Hozak",
                    "initials": "RR",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2182553763"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Indianapolis, IN (United States)",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Ling",
                    "last_name": "Yang",
                    "initials": "L",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2250633597"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Jonathan D.",
                    "last_name": "Schwartz",
                    "initials": "JD",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2155041711"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Eli Lilly and Company",
                            "name_original": "Eli Lilly and Company, Bridgewater, NJ, United States.",
                            "ids": [
                                {
                                    "type": "magid",
                                    "value": "168537998"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.417540.3"
                                },
                                {
                                    "type": "fundref",
                                    "value": "100004312"
                                },
                                {
                                    "type": "ror",
                                    "value": "01qat3289"
                                }
                            ],
                            "grid_id": "grid.417540.3",
                            "country_code": "US"
                        }
                    ]
                },
                {
                    "first_name": "Celestia S.",
                    "last_name": "Higano",
                    "initials": "CS",
                    "ids": [
                        {
                            "type": "magid",
                            "value": "2560077320"
                        }
                    ],
                    "affiliations": [
                        {
                            "name": "Fred Hutchinson Cancer Research Center",
                            "name_original": "University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, United States",
                            "ids": [
                                {
                                    "type": "grid",
                                    "value": "grid.270240.3"
                                },
                                {
                                    "type": "ror",
                                    "value": "007ps6h72"
                                }
                            ],
                            "grid_id": "grid.270240.3",
                            "country_code": "US"
                        },
                        {
                            "name": "University of Washington",
                            "name_original": "University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, United States",
                            "ids": [
                                {
                                    "type": "fundref",
                                    "value": "100007812"
                                },
                                {
                                    "type": "orgref",
                                    "value": "31776"
                                },
                                {
                                    "type": "grid",
                                    "value": "grid.34477.33"
                                },
                                {
                                    "type": "ror",
                                    "value": "00cvxb145"
                                }
                            ],
                            "grid_id": "grid.34477.33",
                            "country_code": "US"
                        }
                    ]
                }
            ],
            "source": {
                "title": "European journal of cancer (Oxford, England : 1990)",
                "type": "Journal",
                "publisher": "Elsevier Limited",
                "issn": [
                    {
                        "type": "unknown",
                        "value": "18790852"
                    },
                    {
                        "type": "print",
                        "value": "09598049"
                    }
                ],
                "country": "United Kingdom",
                "asjc_codes": [
                    "1306",
                    "2730"
                ],
                "asjc_subjects": [
                    "Cancer Research",
                    "Oncology"
                ]
            },
            "fields_of_study": [
                "Internal medicine",
                "Oncology",
                "Cixutumumab",
                "Prednisone",
                "Ramucirumab",
                "Prostate cancer",
                "Mitoxantrone",
                "Docetaxel",
                "Regimen",
                "Phases of clinical research",
                "Medicine"
            ],
            "keywords": [
                "Cixutumumab",
                "Mitoxantrone",
                "Prednisone",
                "Prostate cancer",
                "Ramucirumab"
            ],
            "publication_supplementary_type": [
                "clinical trial, phase ii",
                "multicenter study",
                "randomized controlled trial",
                "research support, non-u.s. gov't"
            ],
            "volume": "51",
            "issue": "13",
            "languages": [
                "en"
            ],
            "references": [
                {
                    "lens_id": "003-415-704-045-340"
                },
                {
                    "lens_id": "006-027-163-131-418"
                },
                {
                    "lens_id": "010-839-632-959-305"
                },
                {
                    "lens_id": "013-690-046-069-453"
                },
                {
                    "lens_id": "015-449-984-502-884"
                },
                {
                    "lens_id": "015-767-931-570-158"
                },
                {
                    "lens_id": "018-245-327-947-052"
                },
                {
                    "lens_id": "020-963-415-260-304"
                },
                {
                    "lens_id": "026-332-934-265-841"
                },
                {
                    "lens_id": "028-101-820-366-93X"
                },
                {
                    "lens_id": "032-523-762-689-478"
                },
                {
                    "lens_id": "037-117-740-052-570"
                },
                {
                    "lens_id": "038-557-040-762-884"
                },
                {
                    "lens_id": "040-239-601-782-040"
                },
                {
                    "lens_id": "042-246-996-698-043"
                },
                {
                    "lens_id": "043-024-349-674-734"
                },
                {
                    "lens_id": "043-201-312-439-671"
                },
                {
                    "lens_id": "043-546-849-370-25X"
                },
                {
                    "lens_id": "046-041-414-632-674"
                },
                {
                    "lens_id": "046-648-350-541-685"
                },
                {
                    "lens_id": "046-852-526-558-260"
                },
                {
                    "lens_id": "054-808-246-993-497"
                },
                {
                    "lens_id": "059-727-763-246-876"
                },
                {
                    "lens_id": "065-982-455-260-233"
                },
                {
                    "lens_id": "069-612-901-254-771"
                },
                {
                    "lens_id": "070-794-057-102-152"
                },
                {
                    "lens_id": "083-233-359-584-62X"
                },
                {
                    "lens_id": "087-375-055-670-659"
                },
                {
                    "lens_id": "087-458-139-690-01X"
                },
                {
                    "lens_id": "090-234-280-758-859"
                },
                {
                    "lens_id": "094-489-992-059-749"
                },
                {
                    "lens_id": "096-654-301-744-608"
                },
                {
                    "lens_id": "101-625-667-760-940"
                },
                {
                    "lens_id": "113-073-836-369-700"
                },
                {
                    "lens_id": "128-335-721-572-401"
                },
                {
                    "lens_id": "155-152-241-876-905"
                }
            ],
            "mesh_terms": [
                {
                    "mesh_heading": "Adenocarcinoma",
                    "qualifier_name": "drug therapy",
                    "mesh_id": "D000230",
                    "qualifier_id": "Q000188"
                },
                {
                    "mesh_heading": "Adolescent",
                    "mesh_id": "D000293"
                },
                {
                    "mesh_heading": "Adult",
                    "mesh_id": "D000328"
                },
                {
                    "mesh_heading": "Aged",
                    "mesh_id": "D000368"
                },
                {
                    "mesh_heading": "Antibodies, Monoclonal",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D000911",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Antibodies, Monoclonal, Humanized",
                    "mesh_id": "D061067"
                },
                {
                    "mesh_heading": "Antineoplastic Combined Chemotherapy Protocols",
                    "qualifier_name": "adverse effects",
                    "mesh_id": "D000971",
                    "qualifier_id": "Q000009"
                },
                {
                    "mesh_heading": "Disease Progression",
                    "mesh_id": "D018450"
                },
                {
                    "mesh_heading": "Disease-Free Survival",
                    "mesh_id": "D018572"
                },
                {
                    "mesh_heading": "Docetaxel",
                    "mesh_id": "D000077143"
                },
                {
                    "mesh_heading": "Humans",
                    "mesh_id": "D006801"
                },
                {
                    "mesh_heading": "Kaplan-Meier Estimate",
                    "mesh_id": "D053208"
                },
                {
                    "mesh_heading": "Male",
                    "mesh_id": "D008297"
                },
                {
                    "mesh_heading": "Middle Aged",
                    "mesh_id": "D008875"
                },
                {
                    "mesh_heading": "Mitoxantrone",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D008942",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Prednisone",
                    "qualifier_name": "administration & dosage",
                    "mesh_id": "D011241",
                    "qualifier_id": "Q000008"
                },
                {
                    "mesh_heading": "Proportional Hazards Models",
                    "mesh_id": "D016016"
                },
                {
                    "mesh_heading": "Prostatic Neoplasms, Castration-Resistant",
                    "qualifier_name": "drug therapy",
                    "mesh_id": "D064129",
                    "qualifier_id": "Q000188"
                },
                {
                    "mesh_heading": "Taxoids",
                    "qualifier_name": "therapeutic use",
                    "mesh_id": "D043823",
                    "qualifier_id": "Q000627"
                },
                {
                    "mesh_heading": "Time Factors",
                    "mesh_id": "D013997"
                },
                {
                    "mesh_heading": "Treatment Outcome",
                    "mesh_id": "D016896"
                },
                {
                    "mesh_heading": "United States",
                    "mesh_id": "D014481"
                },
                {
                    "mesh_heading": "Young Adult",
                    "mesh_id": "D055815"
                }
            ],
            "chemicals": [
                {
                    "substance_name": "Antibodies, Monoclonal",
                    "registry_number": "0",
                    "mesh_id": "D000911"
                },
                {
                    "substance_name": "Antibodies, Monoclonal, Humanized",
                    "registry_number": "0",
                    "mesh_id": "D061067"
                },
                {
                    "substance_name": "Taxoids",
                    "registry_number": "0",
                    "mesh_id": "D043823"
                },
                {
                    "substance_name": "Docetaxel",
                    "registry_number": "15H5577CQD",
                    "mesh_id": "D000077143"
                },
                {
                    "substance_name": "cixutumumab",
                    "registry_number": "2285XW22DR",
                    "mesh_id": "C557414"
                },
                {
                    "substance_name": "Mitoxantrone",
                    "registry_number": "BZ114NVM5P",
                    "mesh_id": "D008942"
                },
                {
                    "substance_name": "ramucirumab",
                    "registry_number": "D99YVK4L0X",
                    "mesh_id": "C543333"
                },
                {
                    "substance_name": "Prednisone",
                    "registry_number": "VB0R961HZT",
                    "mesh_id": "D011241"
                }
            ],
            "clinical_trials": [
                {
                    "id": "nct00683475",
                    "registry": "10.18810/clinical-trials-gov"
                }
            ],
            "funding": [
                {
                    "org": "NCI NIH HHS",
                    "funding_id": "P30 CA008748",
                    "country": "United States"
                }
            ],
            "source_urls": [
                {
                    "type": "html",
                    "url": "https://www.scholars.northwestern.edu/en/publications/a-randomised-non-comparative-phase-ii-trial-of-cixutumumab-imc-a1"
                },
                {
                    "type": "html",
                    "url": "https://www.sciencedirect.com/science/article/pii/S0959804915004505"
                },
                {
                    "type": "html",
                    "url": "https://core.ac.uk/display/82196673"
                },
                {
                    "type": "html",
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26082390"
                },
                {
                    "type": "html",
                    "url": "https://europepmc.org/abstract/MED/26082390"
                },
                {
                    "type": "html",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26082390/"
                },
                {
                    "type": "unknown",
                    "url": "https://www.sciencedirect.com/science/article/abs/pii/S0959804915004505#!"
                },
                {
                    "type": "core_fulltext",
                    "url": "https://core.ac.uk/download/pdf/82196673.pdf"
                }
            ],
            "abstract": "Abstract Background Cixutumumab, a human monoclonal antibody (HuMAb), targets the insulin-like growth factor receptor. Ramucirumab is a recombinant HuMAb that binds to vascular endothelial growth factor receptor-2. A non-comparative randomised phase II study evaluated cixutumumab or ramucirumab plus mitoxantrone and prednisone (MP) in metastatic castration-resistant prostate cancer (mCRPC). Patients and methods Men with progressive mCRPC during or after docetaxel therapy received mitoxantrone 12 mg/m2 on day 1 and prednisone 5 mg twice daily and were randomised 1:1 to receive either cixutumumab or ramucirumab 6 mg/kg intravenously weekly in a 21-day cycle. Primary end-point was composite progression-free survival (cPFS). Secondary end-points included safety, response, radiographic progression-free survival (PFS) and overall survival (OS). Sample size was based on a 50% increase in median cPFS from 2.6 (MP) to 3.9 months (either combination). Results 132 men were treated (66 per arm). Median cPFS was 4.1 months (95% confidence interval (CI), 2.2–5.6) for cixutumumab and 6.7 months (95% CI, 4.5–8.3) for ramucirumab. Median time to radiographic progression was 7.5 months for cixutumumab and 10.2 months for ramucirumab, with a median OS of 10.8 and 13.0 months, respectively. Fatigue was the most frequent adverse event (AE). Incidence of most non-haematologic grade 3–4 AEs was Conclusion Combinations of cixutumumab or ramucirumab plus MP were feasible and associated with moderate toxicities in docetaxel-pretreated men with mCRPC. Of the two regimens, the ramucirumab regimen is worthy of further testing based on the observed cPFS relative to the historical control.",
            "references_count": 36,
            "scholarly_citations_count": 27,
            "start_page": "1714",
            "end_page": "1724",
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